Nai De is an antiviral medication. Nai De must be used together with an interferon alfa product to treat chronic hepatitis C. Nai De may also be used for purposes not listed in Nai De guide.
Nai De side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Nai De and call your doctor at once if you have a serious side effect such as:
problems with your vision;
fever, chills, body aches, flu symptoms;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
stabbing chest pain, wheezing, feeling short of breath;
severe depression, hallucinations, thoughts of suicide or hurting yourself;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
pale or yellowed skin, dark colored urine, easy bruising or bleeding, confusion, or unusual weakness.
Less serious side effects may include:
headache;
muscle pain;
dry mouth;
nausea; vomiting, stomach pain, loss of appetite;
weight loss;
feeling tired or irritable;
anxiety, mood changes; or
pain, swelling, or irritation where the interferon injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects
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Nai De dosing
Usual Adult Dose for Chronic Hepatitis C:
CAPSULES, ORAL SOLUTION: In combination with peginterferon alfa-2b: Less than 66 kg: 400 mg orally twice a day 66 to 80 kg: 400 mg orally in the morning and 600 mg in the evening 81 to 105 kg: 600 mg orally twice a day Greater than 105 kg: 600 mg orally in the morning and 800 mg in the evening Duration of therapy: -Interferon alpha-naive patients with genotype 1: 48 weeks -Interferon alpha-naive patients with genotype 2 and 3: 24 weeks -Retreatment with peginterferon alfa-2b/ribavirin of prior treatment failures: 48 weeks, regardless of HCV genotype In combination with interferon alfa-2b: 75 kg or less: 400 mg orally in the morning and 600 mg in the evening Greater than 75 kg: 600 mg orally twice a day Duration of therapy: -Interferon alpha-naive patients: 24 to 48 weeks -Retreatment with interferon alfa-2b/ribavirin in patients who relapse after nonpegylated interferon monotherapy: 24 weeks Comments: -The manufacturer's product information for peginterferon alfa-2b or interferon alfa-2b should be consulted. -Combination therapy with peginterferon alfa-2b is preferred; provides substantially better response rates than combination therapy with interferon alfa-2b. -Patients with previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and/or genotype 1 infection are less likely to benefit from retreatment after a failing course of therapy. Approved indication: In combination with peginterferon alfa-2b or interferon alfa-2b, for treatment of chronic hepatitis C in patients with compensated liver disease TABLETS: In combination with peginterferon alfa-2a: -Genotypes 1 and 4 in patients less than 75 kg: 1000 mg/day orally in 2 divided doses for 48 weeks -Genotypes 1 and 4 in patients 75 kg or more: 1200 mg/day orally in 2 divided doses for 48 weeks -Genotypes 2 and 3: 800 mg/day orally in 2 divided doses for 24 weeks -Genotypes 5 and 6: Insufficient data to make a recommendation -In patients coinfected with HIV: 800 mg/day orally in 2 divided doses for 48 weeks, regardless of HCV genotype Comments: -The manufacturer's product information for peginterferon alfa-2a should be consulted. Approved indication: In combination with peginterferon alfa-2a, for treatment of patients with chronic hepatitis C who have compensated liver disease and have not been previously treated with interferon alfa
Usual Adult Dose for Respiratory Syncytial Virus:
Case Review: One vial (6 g) dissolved and delivered through a Small Particle Aerosol Generator (SPAG-2) over a continuous 22-hour period, daily for 5 consecutive days
Usual Pediatric Dose for Respiratory Syncytial Virus:
20 mg/mL as the starting solution in the drug reservoir of the SPAG-2 unit, with continuous aerosol administration for 12 to 18 hours per day for 3 to 7 days Comments: -The operator's manual for the SPAG-2 should be consulted. -Using 20 mg/mL, the aerosol concentration for a 12-hour delivery period averages 190 mcg/L of air. -Ribavirin should not be administered simultaneously or combined with any other aerosolized medications. -Sudden deterioration of respiratory function has been associated with initiation of Nai De inhalation therapy in infants; careful monitoring of respiratory function during therapy recommended. If initiation of inhaled Nai De produces sudden deterioration of respiratory function, therapy should be discontinued and restarted only with extreme caution, continuous monitoring, and coadministration of bronchodilators should be considered. Approved indication: For treatment of hospitalized infants and young children with severe lower respiratory tract infections due to respiratory syncytial virus
Usual Pediatric Dose for Chronic Hepatitis C:
CAPSULES, ORAL SOLUTION: 3 years or older: In combination with peginterferon alfa-2b or interferon alfa-2b: 15 mg/kg orally per day in 2 divided doses Nai De dosages according to weight: Less than 47 kg: 15 mg/kg orally per day in 2 divided doses 47 to 59 kg: 400 mg orally twice a day 60 to 73 kg: 400 mg orally in the morning and 600 mg in the evening Greater than 73 kg: 600 mg orally twice a day Duration of therapy: -Genotype 1: 48 weeks -Genotypes 2 and 3: 24 weeks Comments: -The manufacturer's product information for peginterferon alfa-2b or interferon alfa-2b should be consulted. -Combination therapy with peginterferon alfa-2b is preferred; provides substantially better response rates than combination therapy with interferon alfa-2b. -Patients who reach their 18th birthday while receiving peginterferon alfa-2b plus Nai De should remain on the pediatric dosing regimen. -Patients with previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and/or genotype 1 infection are less likely to benefit from retreatment after a failing course of therapy. Approved indication: In combination with peginterferon alfa-2b or interferon alfa-2b, for treatment of chronic hepatitis C in patients with compensated liver disease TABLETS: 5 years or older: In combination with peginterferon alfa-2a: 23 to 33 kg: 200 mg orally twice a day 34 to 46 kg: 200 mg orally in the morning and 400 mg in the evening 47 to 59 kg: 400 mg orally twice a day 60 to 74 kg: 400 mg orally in the morning and 600 mg in the evening 75 kg or more: 600 mg orally twice a day Duration of therapy: -Genotype 2 and 3: 24 weeks -Other genotypes: 48 weeks Comments: -The manufacturer's product information for peginterferon alfa-2a should be consulted. -Patients who reach their 18th birthday while receiving peginterferon alfa-2a plus Nai De should remain on the pediatric dosing regimen. Approved indication: In combination with peginterferon alfa-2a, for treatment of patients with chronic hepatitis C who have compensated liver disease and have not been previously treated with interferon alfa
Dailymed."Ribavirin: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Can Nai De be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
How should I take Nai De?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Nai De is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product to treat chronic hepatitis C.
Take this medicine with food.
Measure the liquid form of Nai De with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Nai De may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. Your blood will need to be tested often. Your vision, liver function, and thyroid function may also need to be tested. Visit your doctor regularly.
Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.
Use Nai De regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Drink extra fluids while you are taking Nai De to keep from getting dehydrated, especially during exercise or in hot weather.
Nai De can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking Nai De, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.
Store Nai De tablets and capsules at room temperature away from moisture, heat, and light.
Store Nai De liquid (oral solution) in the refrigerator. Do not allow it to freeze.
Who should not take Nai De?
You should not take Nai De if you are allergic to it, or if you have:
severe liver disease ;
autoimmune hepatitis;
a hemoglobin disorder such as anemia, thalassemia (Mediterranean anemia), or sickle-cell anemia;
if you are also taking didanosine (Videx); or
if you are pregnant woman, or a man whose female sexual partner is pregnant.
To make sure you can safely take Nai De, tell your doctor if you have any of these other conditions:
kidney or liver disease (other than hepatitis C);
hepatitis B infection;
a blood cell disorder such as hemolytic anemia (a lack of red blood cells);
human immunodeficiency virus (HIV or AIDS);
diabetes;
a pancreas disorder;
sarcoidosis;
breathing problems;
a thyroid disorder;
new or worsening eye problems (such as retinopathy);
a history of heart disease, high blood pressure, or a heart attack;
a history of depression or suicide attempt;
a history of a liver, kidney, or other organ transplant; or
if you have ever received treatment for hepatitis C that did not work well.
This medication can cause birth defects or death in an unborn baby.
If you are a woman, do not take Nai De if you are pregnant. You will need frequent pregnancy tests to make sure you are not pregnant while taking Nai De.
If you are a man, do not take Nai De if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking Nai De. Your sexual partner will need frequent pregnancy tests to make sure she is not pregnant while you are taking Nai De.
Use at least two effective forms of birth control while either sexual partner is taking Nai De, and for at least 6 months after treatment ends.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Nai De.
Your name may need to be listed on a Nai De pregnancy registry if you become pregnant while you or your male sexual partner are taking this medication or during the 6 months after treatment ends. This is to track the outcome of the pregnancy and to evaluate any effects of Nai De on the baby.
It is not known whether Nai De passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Nai De.
Nai De may affect growth in children.
What other drugs will affect Nai De?
Tell your doctor about all other medicines you use, especially:
abacavir (Ziagen);
azathiopriine (Azasan, Imuran);
lamivudine (Combivir, Epivir, Epzicom, Trizivir);
stavudine (Zerit);
tenofovir (Viread);
zalcitabine (Hivid); or
zidovudine (Retrovir, AZT).
This list is not complete and other drugs may interact with Nai De. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Can Nai De be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Nai De be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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Reviews
Following the study conducted by gmedication.com on Nai De, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Nai De. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.
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