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Liv-Up |
What is the medium of administration of the drug? |
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Read drug prescription
What is Liv-Up
Liv-Up is an antiviral medication.Liv-Up must be used together with an interferon alfa product to treat chronic hepatitis C.
Liv-Up may also be used for purposes not listed in Liv-Up guide.
Liv-Up side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Stop using Liv-Up and call your doctor at once if you have a serious side effect such as:
- problems with your vision;
- fever, chills, body aches, flu symptoms;
- severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
- stabbing chest pain, wheezing, feeling short of breath;
- severe depression, hallucinations, thoughts of suicide or hurting yourself;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
- pale or yellowed skin, dark colored urine, easy bruising or bleeding, confusion, or unusual weakness.
Less serious side effects may include:
- headache;
- muscle pain;
- dry mouth;
- nausea; vomiting, stomach pain, loss of appetite;
- weight loss;
- feeling tired or irritable;
- anxiety, mood changes; or
- pain, swelling, or irritation where the interferon injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects
Liv-Up dosing
Usual Adult Dose for Chronic Hepatitis C:
CAPSULES, ORAL SOLUTION:In combination with peginterferon alfa-2b:
Less than 66 kg: 400 mg orally twice a day
66 to 80 kg: 400 mg orally in the morning and 600 mg in the evening
81 to 105 kg: 600 mg orally twice a day
Greater than 105 kg: 600 mg orally in the morning and 800 mg in the evening
Duration of therapy:
-Interferon alpha-naive patients with genotype 1: 48 weeks
-Interferon alpha-naive patients with genotype 2 and 3: 24 weeks
-Retreatment with peginterferon alfa-2b/ribavirin of prior treatment failures: 48 weeks, regardless of HCV genotype
In combination with interferon alfa-2b:
75 kg or less: 400 mg orally in the morning and 600 mg in the evening
Greater than 75 kg: 600 mg orally twice a day
Duration of therapy:
-Interferon alpha-naive patients: 24 to 48 weeks
-Retreatment with interferon alfa-2b/ribavirin in patients who relapse after nonpegylated interferon monotherapy: 24 weeks
Comments:
-The manufacturer's product information for peginterferon alfa-2b or interferon alfa-2b should be consulted.
-Combination therapy with peginterferon alfa-2b is preferred; provides substantially better response rates than combination therapy with interferon alfa-2b.
-Patients with previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and/or genotype 1 infection are less likely to benefit from retreatment after a failing course of therapy.
Approved indication: In combination with peginterferon alfa-2b or interferon alfa-2b, for treatment of chronic hepatitis C in patients with compensated liver disease
TABLETS:
In combination with peginterferon alfa-2a:
-Genotypes 1 and 4 in patients less than 75 kg: 1000 mg/day orally in 2 divided doses for 48 weeks
-Genotypes 1 and 4 in patients 75 kg or more: 1200 mg/day orally in 2 divided doses for 48 weeks
-Genotypes 2 and 3: 800 mg/day orally in 2 divided doses for 24 weeks
-Genotypes 5 and 6: Insufficient data to make a recommendation
-In patients coinfected with HIV: 800 mg/day orally in 2 divided doses for 48 weeks, regardless of HCV genotype
Comments:
-The manufacturer's product information for peginterferon alfa-2a should be consulted.
Approved indication: In combination with peginterferon alfa-2a, for treatment of patients with chronic hepatitis C who have compensated liver disease and have not been previously treated with interferon alfa
Usual Adult Dose for Respiratory Syncytial Virus:
Case Review: One vial (6 g) dissolved and delivered through a Small Particle Aerosol Generator (SPAG-2) over a continuous 22-hour period, daily for 5 consecutive daysUsual Pediatric Dose for Respiratory Syncytial Virus:
20 mg/mL as the starting solution in the drug reservoir of the SPAG-2 unit, with continuous aerosol administration for 12 to 18 hours per day for 3 to 7 daysComments:
-The operator's manual for the SPAG-2 should be consulted.
-Using 20 mg/mL, the aerosol concentration for a 12-hour delivery period averages 190 mcg/L of air.
-Ribavirin should not be administered simultaneously or combined with any other aerosolized medications.
-Sudden deterioration of respiratory function has been associated with initiation of Liv-Up inhalation therapy in infants; careful monitoring of respiratory function during therapy recommended. If initiation of inhaled Liv-Up produces sudden deterioration of respiratory function, therapy should be discontinued and restarted only with extreme caution, continuous monitoring, and coadministration of bronchodilators should be considered.
Approved indication: For treatment of hospitalized infants and young children with severe lower respiratory tract infections due to respiratory syncytial virus
Usual Pediatric Dose for Chronic Hepatitis C:
CAPSULES, ORAL SOLUTION:3 years or older:
In combination with peginterferon alfa-2b or interferon alfa-2b: 15 mg/kg orally per day in 2 divided doses
Liv-Up dosages according to weight:
Less than 47 kg: 15 mg/kg orally per day in 2 divided doses
47 to 59 kg: 400 mg orally twice a day
60 to 73 kg: 400 mg orally in the morning and 600 mg in the evening
Greater than 73 kg: 600 mg orally twice a day
Duration of therapy:
-Genotype 1: 48 weeks
-Genotypes 2 and 3: 24 weeks
Comments:
-The manufacturer's product information for peginterferon alfa-2b or interferon alfa-2b should be consulted.
-Combination therapy with peginterferon alfa-2b is preferred; provides substantially better response rates than combination therapy with interferon alfa-2b.
-Patients who reach their 18th birthday while receiving peginterferon alfa-2b plus Liv-Up should remain on the pediatric dosing regimen.
-Patients with previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and/or genotype 1 infection are less likely to benefit from retreatment after a failing course of therapy.
Approved indication: In combination with peginterferon alfa-2b or interferon alfa-2b, for treatment of chronic hepatitis C in patients with compensated liver disease
TABLETS:
5 years or older:
In combination with peginterferon alfa-2a:
23 to 33 kg: 200 mg orally twice a day
34 to 46 kg: 200 mg orally in the morning and 400 mg in the evening
47 to 59 kg: 400 mg orally twice a day
60 to 74 kg: 400 mg orally in the morning and 600 mg in the evening
75 kg or more: 600 mg orally twice a day
Duration of therapy:
-Genotype 2 and 3: 24 weeks
-Other genotypes: 48 weeks
Comments:
-The manufacturer's product information for peginterferon alfa-2a should be consulted.
-Patients who reach their 18th birthday while receiving peginterferon alfa-2a plus Liv-Up should remain on the pediatric dosing regimen.
Approved indication: In combination with peginterferon alfa-2a, for treatment of patients with chronic hepatitis C who have compensated liver disease and have not been previously treated with interferon alfa
Select the most affordable brand or generic drug
References
- Dailymed."Ribavirin: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "Ribavirin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "Ribavirin". http://www.drugbank.ca/drugs/DB0081... (accessed August 28, 2018).
Liv-Up - Frequently asked Questions
Can Liv-Up be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Who should not take Liv-Up?
You should not take Liv-Up if you are allergic to it, or if you have:
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severe liver disease ;
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autoimmune hepatitis;
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a hemoglobin disorder such as anemia, thalassemia (Mediterranean anemia), or sickle-cell anemia;
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if you are also taking didanosine (Videx); or
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if you are pregnant woman, or a man whose female sexual partner is pregnant.
To make sure you can safely take Liv-Up, tell your doctor if you have any of these other conditions:
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kidney or liver disease (other than hepatitis C);
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hepatitis B infection;
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a blood cell disorder such as hemolytic anemia (a lack of red blood cells);
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human immunodeficiency virus (HIV or AIDS);
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diabetes;
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a pancreas disorder;
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sarcoidosis;
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breathing problems;
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a thyroid disorder;
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new or worsening eye problems (such as retinopathy);
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a history of heart disease, high blood pressure, or a heart attack;
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a history of depression or suicide attempt;
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a history of a liver, kidney, or other organ transplant; or
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if you have ever received treatment for hepatitis C that did not work well.
This medication can cause birth defects or death in an unborn baby.
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If you are a woman, do not take Liv-Up if you are pregnant. You will need frequent pregnancy tests to make sure you are not pregnant while taking Liv-Up.
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If you are a man, do not take Liv-Up if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking Liv-Up. Your sexual partner will need frequent pregnancy tests to make sure she is not pregnant while you are taking Liv-Up.
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Use at least two effective forms of birth control while either sexual partner is taking Liv-Up, and for at least 6 months after treatment ends.
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Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Liv-Up.
Your name may need to be listed on a Liv-Up pregnancy registry if you become pregnant while you or your male sexual partner are taking this medication or during the 6 months after treatment ends. This is to track the outcome of the pregnancy and to evaluate any effects of Liv-Up on the baby.
It is not known whether Liv-Up passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Liv-Up.
Liv-Up may affect growth in children.
What other drugs will affect Liv-Up?
Tell your doctor about all other medicines you use, especially:
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abacavir (Ziagen);
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azathiopriine (Azasan, Imuran);
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lamivudine (Combivir, Epivir, Epzicom, Trizivir);
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stavudine (Zerit);
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tenofovir (Viread);
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zalcitabine (Hivid); or
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zidovudine (Retrovir, AZT).
This list is not complete and other drugs may interact with Liv-Up. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
How should I take Liv-Up?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Liv-Up is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product to treat chronic hepatitis C.
Take this medicine with food.
Measure the liquid form of Liv-Up with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Liv-Up may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. Your blood will need to be tested often. Your vision, liver function, and thyroid function may also need to be tested. Visit your doctor regularly.
Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.
Use Liv-Up regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Drink extra fluids while you are taking Liv-Up to keep from getting dehydrated, especially during exercise or in hot weather.
Liv-Up can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking Liv-Up, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.
Store Liv-Up tablets and capsules at room temperature away from moisture, heat, and light.
Store Liv-Up liquid (oral solution) in the refrigerator. Do not allow it to freeze.
Can Liv-Up be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Liv-Up be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
Reviews
Following the study conducted by gmedication.com on Liv-Up, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Liv-Up. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.Patient reports
One patient reported useful
How active was the Liv-Up in relieving patients of the disease or symptoms?Based on the survey reports from users of gmedication.com, about Useful percentage of users claimed the Liv-Up were useful to them in reducing their symptoms and diseases. However, the effectiveness of the medicine is influenced by many factors like the perception of the symptom, the severity of the conditions, and some other factors; the brand name could also be a factor to an extent. In the event the medicine does not produce the same effective result in your case, ensure you consult your medical expert to reexamine you on your disease or symptoms and prescribe, after that, alternative medications.
| Patients | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
One patient reported side effects
Does the Liv-Up Have Any Side Effects?Based on the survey report from users of gmedication.com, about It has side effects number of people suffered some side effect after consumption of Liv-Up. All drugs have a portion of undesirable side effects. These effects could be irritations too insignificant for the patient to even notice. However, the side effects of drugs may be determined by several factors like severity of disease and conditions associated with individual patients. However, one of the biggest factors is the dosage consumed. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. All patients have their different intensity of side effects. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Liv-Up.
| Patients | % | ||
|---|---|---|---|
| It has side effects | 1 | 100.0% | |
Patient reported price estimates
No survey data has been collected yetOne patient reported frequency of use
How often should I take Liv-Up?According to the survey, gmedication.com reported that users of Liv-Up should take Twice in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.
| Patients | % | ||
|---|---|---|---|
| Twice in a day | 1 | 100.0% | |
Patient reported doses
No survey data has been collected yetPatient reported time for results
No survey data has been collected yetPatient reported administration
No survey data has been collected yetFour patients reported age
| Patients | % | ||
|---|---|---|---|
| 30-45 | 1 | 25.0% | |
| 46-60 | 1 | 25.0% | |
| 6-15 | 1 | 25.0% | |
| 16-29 | 1 | 25.0% | |
Patient reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Vishal Pawar, MD Pharmacology