Toledomin

Name: Toledomin Price Comparison: Uses, Dosage, Form & Side Effects
Creator: gmedication.com
Published: 2021-11-01T10:10:10+00:00

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What is Toledomin
Toledomin side effects
Toledomin dosing

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Frequently asked Questions

Who should not take Toledomin?
What other drugs will affect Toledomin?
How should I take Toledomin?

Toledomin reviews

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What is Toledomin

Toledomin affects certain chemicals in the brain called neurotransmitters. An abnormality in these chemicals is thought to be related to fibromyalgia. Toledomin is not used to treat depression but how it works in the body is similar to how some antidepressants work.
Toledomin is used to treat a chronic pain disorder called fibromyalgia.
Toledomin may also be used for other purposes not listed in Toledomin guide.

Toledomin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive, more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:

pounding heartbeats or fluttering in your chest;
painful or difficult urination;
easy bruising or bleeding, nosebleeds, bloody or tarry stools, coughing up blood;
severe weakness, seizure (convulsions);
chills or goose bumps, memory problems, trouble concentrating,
agitation, hallucinations, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
very stiff (rigid) muscles, high fever, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats); or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

headache;
dizziness, drowsiness, tired feeling;
swelling in your hands or feet;
constipation, upset stomach, bloating;
dry mouth;
sleep problems (insomnia);
hot flashes, sweating;
weight changes; or
decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Toledomin dosing

Usual Adult Dose for Fibromyalgia:

Dosing should be titrated according to the following schedule:
Initial dose on day 1: 12.5 mg once
Days 2 and 3: 12.5 mg twice daily
Days 4 through 7: 25 mg twice daily
After day 7: 50 mg twice daily
Recommended maintenance dose: 50 mg twice daily
Based on individual patient response, the dose may be increased to 100 mg twice daily. Doses above 200 mg/day have not been studied.
Toledomin should be tapered and not abruptly discontinued after extended use.
Toledomin may be given orally with or without food. However, taking Toledomin with food may improve the tolerability of the drug.

Usual Pediatric Dose for Fibromyalgia:

17 years and older:
Dosing should be titrated according to the following schedule:
Initial dose on day 1: 12.5 mg once
Days 2 and 3: 12.5 mg twice daily
Days 4 through 7: 25 mg twice daily
After day 7: 50 mg twice daily
Recommended maintenance dose: 50 mg twice daily
Based on individual patient response, the dose may be increased to 100 mg twice daily. Doses above 200 mg/day have not been studied.
Toledomin should be tapered and not abruptly discontinued after extended use.
Toledomin may be given orally with or without food. However, taking Toledomin with food may improve the tolerability of the drug.

Active ingredients: Milnacipran

Select the most affordable brand or generic drug

Strength	Quantity	Price, USD	Country
Dalcipran
Ixel
Milnacipran
25 mg	100	$72.36	Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
25 mg	100	$136.62	Australia, Canada, NZ, Singapore, Turkey, UK, USA
50 mg	100	$82.82	Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
50 mg	100	$149.48	Australia, Canada, India, Mauritius, NZ, Turkey, UK, USA
Savella 100 mg tablet		$2.13
Milnacipran Arrow
Milnacipran Biogaran
Milnacipran Hydrochloride AFP
Milnacipran Hydrochloride Amel
Milnacipran Hydrochloride JG
Milnacipran Hydrochloride Sawai
Milnacipran Hydrochloride TYK
Milnacipran Hydrochloride Taisho
Milnacipran Hydrochloride Taiyo
Milnacipran Hydrochloride Towa
Tivanyl

References

"Milnacipran". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
"Milnacipran". http://www.drugbank.ca/drugs/DB0489... (accessed August 28, 2018).
"Es1o38j3c4: the unique ingredient identifier (unii) is an alphanumeric substance identifier from the joint fda/usp substance registration system (srs).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

Toledomin - Frequently asked Questions

Can Toledomin be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Who should not take Toledomin?

Do not use Toledomin together with thioridazine (Mellaril), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Toledomin. You must wait at least 14 days after stopping an MAO inhibitor before you can take Toledomin. After you stop taking Toledomin, you must wait at least 5 days before you start taking an MAOI.

You should not use this medication if you are allergic to Toledomin, or if you have untreated or uncontrolled narrow-angle glaucoma.

If you have any of these other conditions, you may need a dose adjustment or special tests:

liver or kidney disease;
heart disease, high blood pressure, heart rhythm disorder;
seizures or epilepsy;
glaucoma;
a bleeding or blood clotting disorder such as hemophilia;
enlarged prostate, urination problems;
bipolar disorder (manic depression);
a history of heavy alcohol use;
a history of suicidal thoughts or actions; or
if you are allergic to aspirin or yellow food dye.

You may have thoughts about suicide while taking this medication, especially if you are younger than 24 years old. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether Toledomin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether Toledomin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication.

Do not give Toledomin to anyone younger than 17 years old without the advice of a doctor.

What other drugs will affect Toledomin?

Before using Toledomin, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Toledomin.

Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Toledomin may cause you to bruise or bleed easily.

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin);
clonidine (Catapres, Clorpres);
a diuretic (water pill);
digoxin (digitalis, Lanoxin);
epinephrine (Epi-Pen);
lithium (Lithobid, Eskalith);
tramadol (Ultram);
tryptophan (sometimes called L-tryptophan);
medicine to treat a psychiatric disorder;
medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma);
migraine headache medicine such as almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Treximet), or zolmitriptan (Zomig); or
an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), desvenlafaxine (Pristiq), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

This list is not complete and other drugs may interact with Toledomin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

How should I take Toledomin?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Take the medicine with food if it upsets your stomach.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Do not stop using Toledomin suddenly, or you could have unpleasant withdrawal symptoms such as dizziness, anxiety, feeling irritable, confusion, headache, ringing in your ears, and sleep problems. Talk to your doctor about how to avoid withdrawal symptoms when you stop using Toledomin.

Store at room temperature away from moisture and heat.

Can Toledomin be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Toledomin be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Toledomin, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Toledomin. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.