Simvofix

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Read drug prescription


infoIt is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Simvofix before taking it.

Simvofix

What is Simvofix

Simvofix is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvofix reduces levels of "bad" cholesterol and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
Simvofix is used to lower cholesterol and triglycerides (types of fat) in the blood.
Simvofix is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.
Simvofix is used in adults and children who are at least 10 years old.
Simvofix may also be used for purposes not listed in Simvofix guide.

Simvofix side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, Simvofix can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Also call your doctor at once if you have:
  • signs of a kidney problem--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice.

Common side effects may include:
  • headache;
  • constipation, nausea, stomach pain; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Simvofix dosing

Usual Adult Dose for Prevention of Cardiovascular Disease:

Usual dosage range: 5 to 40 mg orally once a day in the evening
Patients with CHD or at high risk of CHD:
Initial dose: 10 to 20 mg orally once a day in the evening started simultaneously with diet and exercise
Patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vascular disease, history of stroke or other cerebrovascular disease:
Initial dose: 40 mg orally once a day in the evening
Comments:
-Therapy should be individualized according to patient response.
-Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter.
-Due to the increased risk of myopathy, particularly during the first year of treatment, use of the 80 mg dose should be restricted to patients who have been taking 80 mg for 12 months or more without evidence of muscle toxicity.

Usual Adult Dose for Cardiovascular Risk Reduction:

Usual dosage range: 5 to 40 mg orally once a day in the evening
Patients with CHD or at high risk of CHD:
Initial dose: 10 to 20 mg orally once a day in the evening started simultaneously with diet and exercise
Patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vascular disease, history of stroke or other cerebrovascular disease:
Initial dose: 40 mg orally once a day in the evening
Comments:
-Therapy should be individualized according to patient response.
-Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter.
-Due to the increased risk of myopathy (including rhabdomyolysis), particularly during the first year of treatment, use of the 80 mg dose should be restricted to patients who have been taking 80 mg for 12 months or more without evidence of muscle toxicity.

Usual Adult Dose for Homozygous Familial Hypercholesterolemia:

Recommended dose: 40 mg orally once a day in the evening
Comments:
-Simvofix should be used as an adjunct to other lipid-lowering treatments or alone if such treatments are unavailable.

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:

Less than 10 years: Not recommended
10 years or older:
Initial dose: 10 mg orally once a day in the evening
Maintenance dose: 10 to 40 mg orally once a day in the evening
Maximum dose: 40 mg orally once a day in the evening
Comments:
-Doses should be individualized according to the goal of therapy.
-Dose adjustments should be made at intervals of 4 weeks or more.
-Prior to treatment initiation patients should be placed on a standard cholesterol lowering diet, which should continue during treatment.
Approved indication:
-As an adjunct to diet to reduce total-C, LDL-C, and Apo B levels in adolescent boys and girls who are at least one year postmenarche, 10 to 17 years of age, with HeFH, if after an adequate trial of diet therapy the following findings are present:
1. LDL cholesterol remains 190 mg/dL or greater; or
2. LDL cholesterol remains 160 mg/dL or greater and there is a positive family history of premature cardiovascular disease (CVD) or two or more other CVD risk factors are present in the adolescent patient. The minimum goal of treatment in pediatric and adolescent patients is to achieve a mean LDL-C less than 130 mg/dL.
-The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined.

Compare prices at online shops

infoPrices of the drug can vary in different shops. There will be a variation in price from pharmacy to an online shop. Most online shops will have a little lower price when compared to pharmacy stores, so you need to cross check before buying. Just go to a nearest pharmacy store and check for prices before you decide on buying. You should also be checking and comparing prices among various online stores and should be choosing the affordable and best store. The prices also vary based on brands, and you should note few stores sell specific brands, and you should learn to compare prices of same brand in different stores. Below are the prices of Simvofix medicine in some well-known online stores.

StrengthQuantityPrice, USDCountry
Bal Pharma Limited
10 mg10 Tablet$0.44India

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Select the most affordable brand or generic drug

infoGeneric drug is the basic drug with an active substance in it, and the name of the generic drug is same as active substance most of the times. Like Acetaminophen/Paracetemol is Generic name and it has different brand names like Tylenol, Acimol, Crocin, Calpol etc. All these Brand names contain the same Paracetemol, but the medications are manufactured by different companies, so the different brand names. Generic drug is always cheaper and affordable, and it can be replaced in place of brand name drug prescribed by the healthcare practitioner. The Generic medicine has same properties as branded medicine in terms of uses, indications, doses, side effects, so no need to worry on that. Just select the most affordable generic or branded medicine.

StrengthQuantityPrice, USDCountry
Vastilan 10 mg x 100's $38.00
Vastilan 80 mg x 100's $70.00
10 mg10 Tablet$0.60
Satin 10 mg Tablet $0.06
Satin 10 mg Hinglaj Labs Tablet $0.07
Satin 10mg TAB / 10 $0.60
Satin 10mg Tablet $0.08
SATIN 10MG TABLET 1 strip(s) (10 tablets each) $0.76
Satin 20 mg Tablet $0.10
Satin 20mg TAB / 10 $1.04
Detrovel 10 mg x 3 x 10's $3.55
Lipovas 20 mg x 10 x 3's $14.43
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Simvofix - Frequently asked Questions

Can Simvofix be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Who should not take Simvofix?

You should not take Simvofix if you are allergic to it, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Simvofix. These drugs should not be used while you are taking Simvofix:

  • cyclosporine;

  • danazol;

  • gemfibrozil;

  • nefazodone;

  • an antibiotic--clarithromycin, erythromycin, telithromycin;

  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

  • hepatitis C medications--boceprevir, telaprevir; or

  • HIV/AIDS medication--atazanavir, cobicistat, darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Simvofix, tell your doctor if you are already using any of these other medicines:

  • lomitapide; or

  • heart medication--amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Simvofix is safe for you, tell your doctor if you have:

  • history of liver disease;

  • history of kidney disease;

  • diabetes;

  • a thyroid disorder; or

  • if you drink more than 2 alcoholic beverages daily.

Simvofix can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Simvofix if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Simvofix.

Simvofix may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Simvofix.

What other drugs will affect Simvofix?

Many drugs can interact with Simvofix. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Simvofix, especially:

  • delavirdine;

  • fenofibrate; or

  • fluconazole.

This list is not complete and many other drugs can interact with Simvofix. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

How should I take Simvofix?

Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Simvofix is usually taken at bedtime or with an evening meal. If you take Simvofix more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Simvofix, you may need frequent blood tests at your doctor's office.

You may need to take Simvofix on a long-term basis for the treatment of high cholesterol. You may need to stop using Simvofix for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Simvofix is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Can Simvofix be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Simvofix be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by wDrugs.com on Simvofix, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Simvofix. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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Information checked by Dr. Shikha Narang, MD Pharmacology