Macbutin

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What is the medium of administration of the drug?

Here is the some steps to help you to save money on Macbutin purchase.

Read drug prescription


infoIt is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Macbutin before taking it.

Macbutin

What is Macbutin

Macbutin is an antibiotic. It prevents bacteria from multiplying in your body.
Macbutin is used to prevent mycobacterium avium complex in people with HIV (human immunodeficiency virus) infection. Macbutin is also used with other medications to treat tuberculosis in people with HIV.
Macbutin is often given together with other antibiotics.
Macbutin may also be used for other purposes not listed in Macbutin guide.

Macbutin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
  • severe skin rash or itching;
  • pale skin, weakness, easy bruising or bleeding;
  • fever, chills, body aches, flu symptoms; or
  • eye pain or redness, vision loss.

Less serious side effects may include:
  • red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools;
  • nausea, vomiting, diarrhea;
  • stomach pain;
  • belching, bloating, loss of appetite;
  • headache; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Macbutin dosing

Usual Adult Dose for Mycobacterium avium-intracellulare -- Prophylaxis:

300 mg orally once a day. If nausea of vomiting becomes a problem, Macbutin 150 mg orally every 12 hours is an alternative regimen.

Usual Adult Dose for Mycobacterium avium-intracellulare -- Treatment:

300 mg orally once a day. If nausea or vomiting becomes a problem, Macbutin 150 mg orally every 12 hours is an alternative regimen. Therapy often consists of clarithromycin and 2-4 other drugs such as ethambutol, rifampin, clofazimine, and/or other agents. The duration of treatment is generally 18 to 24 months. In immunocompromised patients therapy often consists of clarithromycin or azithromycin and 1 to 3 other drugs such as ethambutol, clofazimine, ciprofloxacin, ofloxacin, rifampin, Macbutin, or amikacin. As long as a clinical and microbiological response is documented, therapy should be continued for life.

Usual Adult Dose for Tuberculosis -- Prophylaxis:

300 mg orally once a day. If nausea of vomiting becomes a problem, Macbutin 150 mg orally every 12 hours is an alternative regimen.
Macbutin is recommended by the USPHS/IDSA Prevention of Opportunistic Infections Working Group as an alternative to rifampin for chemoprophylaxis when exposure to isoniazid-resistant tuberculosis is suspected.
For HIV-infected patients, chemoprophylaxis is recommended for those with a positive tuberculin skin test (greater than or equal to 5 mm), prior positive skin test result without treatment, or contact with cases of active tuberculosis. In addition, tuberculin skin test negative, HIV-infected patients from high risk groups or geographic areas with a high prevalence of Mycobacterium tuberculosis may be candidates for chemoprophylaxis. Active tuberculosis should be ruled out prior to initiating preventive therapy.
There isn't general agreement on how to use Macbutin for preventive therapy. The decision to use non-isoniazid-containing regimens for chemoprophylaxis should require consultation with public health authorities.
Macbutin is typically administered for 6 months to prevent the development of active tuberculosis in patients with no complicating factors. Patients with complicating factors such as HIV infection, diabetes, hematologic malignancy, or scars on chest X-ray should receive prophylaxis for 12 months.

Usual Adult Dose for Tuberculosis -- HIV Positive:

300 mg orally once a day. If nausea of vomiting becomes a problem, Macbutin 150 mg orally every 12 hours is an alternative regimen.
Due to the serious public and personal health risk associated with TB, the American Thoracic Society and the Centers for Disease Control strongly recommend giving anti-TB drugs in a directly observed therapy (DOT) program. If daily self-administered therapy is used, many experts strongly recommend use of combination preparations to decrease the chance of medication noncompliance.
The duration of therapy depends on the susceptibility of the organism. Pulmonary TB should be treated for a minimum of 6 months. In HIV-positive individuals, some experts believe that therapy should be continued for at least 9 months or 6 months beyond culture conversion. This practice is controversial. The current ATS/CDC recommendations are to treat TB in patients with HIV no differently than in those who are HIV-negative. However, before administering rifampin, providers must take into consideration the important drug-drug interactions that exist between rifampin and the non-nucleoside reverse transcriptase inhibitor and protease inhibitor agents used to treat HIV infection. Macbutin is a safer agent to use in HIV-infected individuals taking certain antiretroviral agents.
In general, six-month regimens are effective if pyrazinamide (PZA) and isoniazid (INH) are included in the first two months of therapy. Recommended regimens are as follows.
Rate of INH resistance known to be less than 4%: Daily rifampin (RIF) or Macbutin (RFB) + INH + PZA for 2 months, followed by daily RIF or RFB + INH therapy for 4 months. If susceptibility test confirms INH resistance then follow regimen for INH resistant TB.
Rate of INH resistance is greater than or equal to 4% or unknown (and the patient will be compliant): Daily RIF or RFB + INH + PZA + either streptomycin (SM) or ethambutol (ETB) until susceptibility data is available. If no INH resistance, then continue with daily RIF or RFB + INH + PZA for a total of 2 months and finish with RIF or RFB + INH daily to complete 6 months of therapy. If confirmed INH resistance, then follow regimen for INH resistant TB.
Rate of INH resistance is greater than or equal to 4% or unknown (and the patient is noncompliant or unreliable): DOT with daily RIF or RFB + INH + PZA + either SM or ETB for 2 weeks then 2 to 3 times a week for 6 weeks. Therapy should then be continued with RIF or RFB + INH 2 to 3 times a week to complete 6 months of therapy. An alternative DOT regimen is RIF or RFB + INH + PZA + either SM or ETB 3 times a week for 6 months. Once susceptibility data is available and INH resistance is confirmed then follow regimen for INH resistant TB.
Confirmed INH resistant TB: DOT with daily RIF or RFB + ETB + PZA for 18 months or until sputum is culture negative for at least 12 months. If possible, the treatment of drug-resistant TB should be discussed with an expert in the treatment of such patients.

Usual Pediatric Dose for Mycobacterium avium-intracellulare -- Treatment:

5 mg/kg/day orally has been used in a limited number of cases. Used in combination with at least 2 other antimicrobials. Doses of Macbutin may be administered mixed with foods such as applesauce.
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Select the most affordable brand or generic drug

infoGeneric drug is the basic drug with an active substance in it, and the name of the generic drug is same as active substance most of the times. Like Acetaminophen/Paracetemol is Generic name and it has different brand names like Tylenol, Acimol, Crocin, Calpol etc. All these Brand names contain the same Paracetemol, but the medications are manufactured by different companies, so the different brand names. Generic drug is always cheaper and affordable, and it can be replaced in place of brand name drug prescribed by the healthcare practitioner. The Generic medicine has same properties as branded medicine in terms of uses, indications, doses, side effects, so no need to worry on that. Just select the most affordable generic or branded medicine.

StrengthQuantityPrice, USDCountry
Mycobutin 150 mg capsule $13.01
150 mg6 Capsule$3.75
150 mg x 6's $3.75
RIBUTIN cap 150 mg x 6's $3.75
RIBUTIN 150 MG CAPSULE 1 strip(s) (6 capsules each) $4.96
Ributin 150mg Capsule $0.91
150 mg30 $171.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
150 mg30 $212.85Canada, UK
150 mg30 $229.99Canada, Mauritius, Singapore, Turkey, UK, USA
150 mg90 $533.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
150 mg100 $537.80Canada, UK
150 mg100 $549.99Canada, Mauritius, Singapore, Turkey, UK, USA
150 mg100 $576.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
150 mg100 $578.00Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
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Macbutin - Frequently asked Questions

Can Macbutin be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take Macbutin?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

You may take Macbutin with or without food. Take the medication with food if it causes stomach upset, nausea, or vomiting.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Store Macbutin at room temperature away from moisture and heat. Keep the bottle tightly closed.

Who should not take Macbutin?

You should not take this medication if you are allergic to Macbutin, rifapentine, or rifampin (Rifadin, Rifater, Rimactane, Rifamate).

Macbutin should not be used without other antibiotics to prevent mycobacterium avium complex (MAC) infection in people with active tuberculosis. The tuberculosis may become resistant to treatment if Macbutin is used as a single medication. Be sure to take all your medications as prescribed by your doctor.

Before using Macbutin, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need a dose adjustment or special tests to safely take Macbutin. Your doctor will tell you if any of your medication doses need to be changed.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Macbutin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Macbutin.

It is not known whether Macbutin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Macbutin may cause a red-orange discoloration of breast milk.

What other drugs will affect Macbutin?

The following drugs can interact with Macbutin. Tell your doctor if you are using any of these:

  • other antibiotics such as clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Ery-Tab), fluconazole (Diflucan), or itraconazole (Sporanox); or

  • HIV or AIDS medications such as amprenavir (Agenerase), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), or saquinavir (Invirase, Fortovase).

There are many other medicines that can interact with Macbutin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Can Macbutin be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Macbutin be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by wDrugs.com on Macbutin, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Macbutin. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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Information checked by Dr. Shikha Narang, MD Pharmacology