Ebetrexat

How old is patient? < 1 1-5 6-15 16-29 30-45 46-60 > 60

Here is the some steps to help you to save money on Ebetrexat purchase.

• Read drug prescription
• What is Ebetrexat
• Ebetrexat side effects
• Ebetrexat dosing
• Select the most affordable brand or generic drug
• Frequently asked Questions
• What other drugs will affect Ebetrexat?
• Who should not take Ebetrexat?
• How should I take Ebetrexat?
• Ebetrexat reviews

Read drug prescription

What is Ebetrexat

Ebetrexat interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Ebetrexat is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Ebetrexat is also used to treat severe psoriasis and rheumatoid arthritis.
Ebetrexat is usually given after other medications have been tried without successful treatment of symptoms.
Ebetrexat may also be used for purposes not listed in Ebetrexat guide.

Ebetrexat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Ebetrexat and call your doctor at once if you have:

• dry cough, shortness of breath;
• diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
• blood in your urine or stools;
• swelling, rapid weight gain, little or no urinating;
• seizure (convulsions);
• fever, chills, body aches, flu symptoms;
• pale skin, easy bruising, unusual bleeding, weakness, feeling light-headed or short of breath;
• liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Older adults may be more likely to have side effects from this medicine.
Common side effects may include:

• vomiting, upset stomach;
• headache, dizziness, tired feeling; or
• blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Ebetrexat dosing

Usual Adult Dose for Acute Lymphoblastic Leukemia:

Induction: 3.3 mg/m2/day orally or IM.
Maintenance (during remission): 15 mg/m2 IM or orally twice a week.
Alternate remission dosing: 2.5 mg/kg IV every 14 days.

Usual Adult Dose for Choriocarcinoma:

15 to 30 mg IM or orally daily for 5 days. Repeat courses 3 to 5 times with a rest period of greater than or equal to 1 week between courses, until any manifesting toxic symptoms subside.
Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin (hCG), which generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of Ebetrexat after normalization of hCG is usually recommended.

Usual Adult Dose for Trophoblastic Disease:

15 to 30 mg IM or orally daily for 5 days. Repeat courses 3 to 5 times with a rest period of greater than or equal to 1 week between courses, until any manifesting toxic symptoms subside.
Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin, which generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of Ebetrexat after normalization of hCG is usually recommended.

Usual Adult Dose for Lymphoma:

For Burkitt's tumor in Stages I-II: 10 to 25 mg orally once a day for 4 to 8 days
Malignant lymphoma in Stage III: 0.625 to 2.5 mg/kg orally daily as a part of combination chemotherapy.
Treatment in all stages usually consists of several courses of the drug interposed with 7 to 10 day rest periods.

Usual Adult Dose for Meningeal Leukemia:

12 mg/m2 intrathecally every 2 to 5 days until the cell count of the CSF returns to normal. At this point, one additional dose is advisable. Administration at intervals of less than 1 week may result in increased subacute toxicity.

Usual Adult Dose for Mycosis Fungoides:

2.5 to 10 mg PO daily or 50 mg IM once a week or 25 mg IM twice a week.

Usual Adult Dose for Osteosarcoma:

Initial Dose: 12 g/m2 intravenously as a 4 hour infusion. If this dose is not adequate to achieve a peak serum concentration of 1000 micromolar at the end of the infusion, the dose may be increased to 15 g/m2.
Treatments may occur at 4, 5, 6, 7, 11, 12, 15, 16, 29, 30, 44, and 45 weeks after surgery.
If the patient is vomiting or unable to tolerate oral medication, leucovorin should be added to this regimen at the same dose and schedule as the Ebetrexat.

Usual Adult Dose for Psoriasis:

Single Dose: 10 to 25 mg/week orally, subcutaneously, IM, or IV until adequate response is achieved.
Divided Dose: 2.5 mg orally, IM, or IV every 12 hours for 3 doses once a week.
Maximum weekly dose: 30 mg.

Usual Adult Dose for Rheumatoid Arthritis:

Single dose: 7.5 mg orally weekly.
Divided dose: 2.5 mg orally every 12 hours for 3 doses once a week.
Maximum weekly dose: 20 mg
Patients may be switched from oral Ebetrexat to weekly subcutaneous injections taking into account the increased bioavailability relative to the oral formulation.

Usual Adult Dose for Neoplastic Diseases:

I.V.: Range is wide from 30-40 mg/m2/week to 100-12,000 mg/m2 with leucovorin rescue

Usual Pediatric Dose for Acute Lymphocytic Leukemia:

100 mg/m2 over 1 hour followed by a 35 hour infusion delivering 900 mg/m2/day.

Usual Pediatric Dose for Dermatomyositis:

15 to 20 mg/m2 orally once weekly.

Usual Pediatric Dose for Meningeal Leukemia:

less than 4 months: 3 mg/dose intrathecally.
greater than or equal to 4 months less than 1 year: 6 mg/dose intrathecally.
greater than or equal to 1 year less than 2 years: 8 mg/dose intrathecally.
greater than or equal to 2 years less than 3 years: 10 mg/dose intrathecally.
greater than or equal to 3 years: 12 mg/dose intrathecally.
The dose may be administered every 2 to 5 days until CSF counts return to normal followed by a dose administered once weekly for 2 weeks and monthly thereafter. Administration at intervals of less than 1 week may result in increased subacute toxicity.

Usual Pediatric Dose for Neoplastic Diseases:

7.5 to 30 mg/m2 IM or orally every 2 weeks.
Alternate dosing: 10 to 18,000 mg/m2 IV bolus or continuous infusion over 6 to 42 hours.

Usual Pediatric Dose for Rheumatoid Arthritis:

5 to 15 mg/m2 IM or orally once weekly.
Subcutaneous injection for Polyarticular Juvenile Idiopathic Arthritis: 10 mg/m2 subcutaneously once weekly.

Usual Pediatric Dose for Solid Tumors:

less than 12 years: 12000 mg/m2 IV.
greater than or equal to 12 years: 8000 mg/m2 IV.
Maximum dose: 18 grams.

Active ingredients: Methotrexate

Select the most affordable brand or generic drug

Strength	Quantity	Price, USD	Country
0.4 ML Methotrexate 37.5 MG/ML Auto-Injector [Otrexup]
0.4 ML Otrexup 18.8 MG/ML Auto-Injector
0.5 ML Methotrexate 50 MG/ML Auto-Injector
0.55 ML Rasuvo 50 MG/ML Auto-Injector
Alltrex
2 .5 mg x 100's		$4.76
50 mg x 2 mL x 1's		$0.94
Antifolan
Artrait
Bertanel
Biotrexate
2 .5mg	10 Tablet	$0.59
5 mg x 1's		$0.32
2 .5 mg x 10's		$0.59
Biotrexate 100mg x 1mL VAL / 5ml		$8.19
Carditrex (25 mg)
2 .5mg	10 Tablet	$0.46
2 .5 mg x 10's		$0.46
Darmatrex (5mg)
5 mg	10 Tablet	$0.94
Methorex (25 mg)
Methorex 2.5mg TAB / 10		$0.23
METHOREX inj 25 mg x 1 mL x 2ml		$0.70	Zydus (G.Rem)
100 mg x 1 mL x 10ml		$12.10
Methotrexat - 1 A Pharma
Methotrexate - Wanma Pharm
Methotrexate Acdima
Methotrexate Sandoz
Methotrexate Sodium Bioniche
Methotrexate Tecnofarma
Methrexx
Metodik
Metotab
Metotrexato LKM
Neotrexate
Neotrexate 50mg Injection		$0.36	Glaxo SmithKline Pharmaceuticals Ltd
NEOTREXATE 2.5 MG TABLET 1 strip(s) (10 tablets each)		$0.72	Glaxo SmithKline Pharmaceuticals Ltd
Otrexup 15 MG in 0.4 ML Auto-Injector
Otrexup 22.5 MG in 0.4 ML Auto-Injector
Otrexup 7.5 MG in 0.4 ML Auto-Injector
Plastomet (50mg)
2 .5mg	10 Tablet	$0.36
50 mg	2 ml	$0.84
PLASTOMET tab 2.5 mg x 10's		$0.36	Khandelwal
2 .5 mg x 100's		$3.64
Plastomet 2.5mg TAB / 100		$3.64
50 mg x 2 mL x 1's		$0.84
PLASTOMET inj 50 mg x 2 mL x 2ml		$0.84	Khandelwal
Plastomet 50mg/2mL VIAL / 1		$0.84
Rasuvo (as methotrexate sodium) 50 MG/ML in 0.3 ML Auto-Injector
Rasuvo 12.5 MG per 0.25 ML Auto-Injector
Rasuvo 25 MG per 0.5 ML Auto-Injector
Rheumatrex Dose Pack
2 .5mg	8	$50.00
Rheumatrex Dose Pack 24, 4 Wk Pack
Trexall 15 MG Oral Tablet
methotrexate (as methotrexate sodium) 50 MG/ML in 0.45 ML Auto-Injector
10 mg	100	$112.64	Barbados, Canada, NZ, UK
10 mg	100	$147.02	Canada, UK
2 .5mg	10	$0.24
2 .5mg	30	$18.78	USA
2 .5mg	90	$61.40	USA
2 .5mg	100	$49.00	Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
2 .5mg	100	$58.00	Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
2 .5mg	100	$58.58	Australia, Canada, India, Mauritius, NZ, Turkey, UK, USA
2 .5mg	100	$68.00	Barbados, Canada, NZ, UK
250 mg/10	100	$126.44	USA
25 mg/ml	1	$95.00	Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
50 mg/2ml	100	$220.60	USA
Rheumatrex 2.5 mg tablet		$11.23
Rheumatrex 8 2.5 mg tablet Disp Pack		$169.98
Methotrexate Sodium 25 mg/ml (pf) Solution 10ml Vial		$24.99
Methotrexate Sodium 25 mg/ml (pf) Solution 40ml Vial		$58.99
methotrexate 10 MG per 0.2 ML Auto-Injector
methotrexate 17.5 MG in 0.35 ML Auto-Injector
methotrexate 2.5 MG (20) (12.5 MG per Week) Oral Tablet Pack
methotrexate 25 MG in 0.5 ML Auto-Injector
{16 (Methotrexate 2.5 MG Oral Tablet) } Pack
{24 (Methotrexate 2.5 MG Oral Tablet) } Pack

References

1. Dailymed."Methotrexate sodium: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
2. "Methotrexate". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
3. "Methotrexate". http://www.drugbank.ca/drugs/DB0056... (accessed August 28, 2018).

Ebetrexat - Frequently asked Questions

Can Ebetrexat be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

What other drugs will affect Ebetrexat?

Many drugs can interact with Ebetrexat. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Ebetrexat, especially:

• azathioprine;

• leucovorin;

• phenytoin;

• probenecid;

• theophylline;

• an antibiotic or sulfa drugs;

• isotretinoin, retinol, tretinoin;

• NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or

• salicylates--aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

This list is not complete and many other drugs can interact with Ebetrexat. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Who should not take Ebetrexat?

You should not use this medicine if you are allergic to Ebetrexat. Do not use Ebetrexat to treat psoriasis or rheumatoid arthritis if you have:

• alcoholism, cirrhosis, or other liver disease;

• a blood cell disorder such as anemia or leukopenia (lack of white blood cells);

• a bone marrow disorder; or

• if you are breast-feeding a baby.

Ebetrexat is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.

To make sure Ebetrexat is safe for you, tell your doctor if you have:

• kidney disease;

• a folate deficiency;

• pneumonia or lung disease;

• stomach ulcers;

• any type of infection; or

• if you are receiving radiation treatments.

Ebetrexat can cause birth defects in an unborn baby. Do not use Ebetrexat to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

You may need to have a negative pregnancy test before starting this treatment.

Use birth control to prevent pregnancy while you are using Ebetrexat, whether you are a man or a woman. Ebetrexat use by either parent may cause birth defects.

If you are a man, use a condom to keep from causing a pregnancy while you are using Ebetrexat. Continue using condoms for at least 90 days after your treatment ends.

If you are a woman, use an effective form of birth control while you are taking Ebetrexat, and for at least one cycle of ovulation after your treatment ends.

Do not give this medicine to a child without the advice of a doctor.

How should I take Ebetrexat?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You must use the correct dose of Ebetrexat for your condition. Ebetrexat is sometimes taken once or twice per week and not every day. Follow the directions on your prescription label. Some people have died after taking Ebetrexat every day by accident. Ask your doctor or pharmacist if you have questions about your dose of Ebetrexat or how often to take it.

Use Ebetrexat regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Ebetrexat can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often, and you may need an occasional liver biopsy. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat.

Can Ebetrexat be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Ebetrexat be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Ebetrexat, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Ebetrexat. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology